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Intravenous Glutathione/Vitamin C information

Glutathione is composed of three amino acids, namely glutamate, cysteine and glycine.  The functions of Glutathione are:

  • Destruction of hydrogen peroxide and other harmful free radicals that trigger inflammation, pigmentation and illness and give rise to accelerated ageing
  • Detoxification of foreign compounds
  • Repair of damaged tissues caused by stress, pollution, the sun, radiation, cigarette smoke, etc.
  • Glutathione acts as a co-enzyme to other enzymes, to facilitate certain bodily processes
  • Glutathione can find its way into mitochondria (the energy supply of cells) and protect it, unlike most other anti-oxidants

The levels of Glutathione and its metabolites are dependent on internal (hormones, inflammation) and external (UV, heat, chemical) factors. Research studies have confirmed that low levels of Glutathione are linked to darker pigment.

Studies have proven that oxidative stress plays an important role in hormonal pigmentation (melasma).  These studies confirm that people with melasma have significantly higher levels of Glutathione peroxidase enzyme and other pro-oxidant parameters, which deplete Glutathione in the serum and at cellular level.

Glutathione has a direct inhibiting effect on tyrosinase (the enzyme responsible for pigment production), which is a rate-limiting step in pigment production, and therefore, inhibiting this step has a major impact on pigment production.   Glutathione also has an indirect effect on the course of the pigment production chain, leading to diversion away from eumelanogenesis (production chain for darker pigment) towards phaemelanogenesis (production chain for lighter pigment), resulting in lighter skin pigmentation.

Vitamin C, also known as ascorbic acid, is necessary for the growth, development and repair of all human tissues. It is involved in the formation of collagen, the absorption of iron, the normal functioning of the immune system, wound healing, and the maintenance of cartilage, bones, and teeth.

The Procedure:

Glutathione will be mixed with Normal Saline, which will be infused via an intravenous line over 20-30 minutes.  Thereafter, Vitamin C (Ascorbic acid), an anti-oxidant, will slowly be injected intravenously over 5 minutes

As Glutathione and Vitamin C are both anti-oxidants, you can expect some symptoms of detoxification, such as nausea, headaches, and lethargy for up to 3 days.

Glutathione is not a bleaching agent, but an anti-oxidant with pigment-suppressing properties.  You can expect the skin to lighten by 1 – 2 shades, comparable to the difference in Caucasian skin between Summer and Winter.  Glutathione should ideally be administered as a course of 6 treatments, 1-2 weeks apart.  The dose will gradually be increased over the first 3 treatments and then maintained throughout the treatment.  The results should be maintained at intervals of 2-4 weeks.

Glutathione is also available as capsules and creams and maintenance can be achieved with homecare.  It is important to realise that intravenous administration of Glutathione and Vitamin C ensures 100% bio-availability, compared to oral supplementation, which is dependent on absorption.


  • Hormonal Pigmentation

  • Chronic Fatigue

  • Poor Immunity/ Recurrent Infection